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We then built the isobologram of the corresponding dose-response curves with a fixed dose ratio of R and compared the expected mixture of the two doses that produced an effect equal to half of the maximal effect produced by the individual drugs and to the experimental value (see later in methods)

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Bruhn, R.L., Stamer, W.D., Herrygers, L.A., Levine, J.A., Noecker, R.J

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Genomic classifier (ColoPrint) to predict outcome and chemotherapy benefit in stage II and III colon cancer patients

Visit 5 (Mailman Segal Center) was scheduled between weeks 6 and 7 (middle visit) to collect the remaining powder in the canister and parents' diaries and to provide new canisters for the next period