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Because its mechanism of action is isolated to cellular enzyme inhibition, it carries a very low risk of negative interactions with central nervous system stimulants or gut hormones

Zhang W, Trachootham D, Liu J, Chen G, Pelicano H, Garcia-Prieto C, et al

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Plasma levels of citrulline was lower in patients with acute GI infection-induced GI injury compared to patients with no infection

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By inhibiting the activity of the inhibitory kappa B kinase (IKK), curcumin prevents the translocation and activation of NF-B, thereby reducing the expression of chemokines and pro-inflammatory cytokines such as TNF-, IL-1 and IL-6, which ultimately attenuates inflammatory responses (Jobin et al., 1999)