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Bisubstrate inhibitors such as NS1, LL320, and II399 based on adenosyl scaffolds have shown promise in this regard 199201

Future research could integrate structural prediction technologies (e.g., AlphaFold-Multimer) with proteomics data to screen or design peptide analogs with multifunctional capabilities, such as neural guidance, angiogenesis, and immunomodulation, thereby constructing a synergistic glycopeptide hydrogel platform

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Increased total neurite length relative to vehicle-treated STZ mice

Foods, 10 (2), Article 379

Mechanisms range from effects on neurotransmitter systems to reduction of oxidative stress, to increased neurotrophic factors like BDNF, to enhanced cerebral blood flow