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Regular moderate exercise can boost glutathione production and enzyme activity, though overtraining may deplete it

Lavie Y, Fiucci G, Liscovitch M (1998) Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells J Biol Chem 273 3238032383 PMID: 9829965 128

GSH research had a great momentum especially in the 1980s, with studies carried out by Meister and his collaborators who contributed to understanding the physiological functions and the metabolism ( Glutathione composition and synthesis The GSH (- L-glutamyl-L-cysteinyl-glycine) is a water-soluble tripeptide formed by the amino-acids glutamic acid, cysteine and glycine (Figure 1) present in the cytoplasm of all cells

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cAMP-responsive element-binding protein 1 is a potent activator of PGC-1 and, thereby, initiates the synthesis of mitochondrial and respiratory chain proteins (Tengan et al., 2012

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