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doi: 10.1021/bi048657a

sitagliptin, vildagliptin, alogliptin, et al) are classical anti-hyperglycemic agents that suppress GLP-1 degradation and prolong the action of the glucose-dependent insulinotropic polypeptide

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53 In addition, KRAS and USP1 can also regulate the expression of BCAT2 in PDAC through the ubiquitin-proteasome pathway: KRAS can stabilize the expression of BCAT2 in PDAC by inhibiting the ubiquitination of BCAT2 by spleen tyrosine kinase (SYK) and E3 ubiquitination ligase TRIM21, 54 while USP1 deubiquitinates the K229 site of BCAT2, and BCAAs promote USP1 protein expression at the translation level through the GCN2-eIF2a pathway

135 Because of their small sizes, most siRNAs accumulate in the kidney after being intravenously administered, achieving concentrations 40 times greater than those in other organs, followed by rapid entry into proximal tubule cells

For instance, for treating stomach cancer, the target would ideally be present on the tumor cells, but not on healthy stomach cells, or both will get attacked by immunotherapy