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Persistent or repeated exposure to non-biodegradable or slowly cleared nanomaterials may therefore shift an initially adaptive microglial response toward chronic neuroinflammation, synaptic dysfunction, and neurodegeneration, particularly in aged or disease-susceptible brains (169)

Taylor MJ

Immunosenescence contributes to: Increased infection risk Slower recovery from illness Reduced vaccine responsiveness Chronic inflammation Greater susceptibility to age-related diseases At the same time , many older adults experience "inflammaging," a state of persistent low-grade inflammation that accelerates biological aging

10.1007/s10787-017-0358-8 12 Berkopic CesarL.GojkovicS.KrezicI.MalekinusicD.ZizekH.Batelja VuleticL.et al (2020)

Eur J Gynaecol Oncol 26 (1): 9094

Avoid sodium azide when it may interfere with downstream applications, especially cell-based assays