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The carrageenan-induced increase in the levels of the cytokine-inducible nitric oxide synthase, IL-1, and IL-6 was abrogated following treatment with CBC

As explained later, these components can cross-talk with other pathways such as the MAPK/ERK1/2 (mitogen activated protein kinase/extracellular signal-regulated kinase 1/2) and PI3/Akt (phosphoinositide 3-kinase/protein kinase B) signaling cascades causing changes in gene expression and modifying cell metabolism and proliferation (47)

and iii) increased oxidative stress, due to the putative role of thiamine in prostaglandin expression, decreased lipid peroxidation as well as expression of nitric oxide synthase (143, 144), and its involvement as a cofactor for TKT in the PPP, master regulator of NADPH homeostasis

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Artesunate attenuates skin hypertrophic scar formation by inhibiting fibroblast activation and EndMT of vascular endothelial cells