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In CHE, the gut microbiota of patients show a significantly reduced Shannon diversity index compared with those without CHE, and specific gut microbial families have been linked to its presence, including Lactobacillales , Enterobacteriaceae , Streptococcaceae , Lachnospiraceae , Clostridiales , and Bacteroidaceae [70]

Vet Clin North Am Small Anim Pract

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Taken together, these results suggest that the maintenance of the cFLIP level requires GOT2-derived aKG production