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Peer review Peer review information Nature Chemistry thanks the anonymous reviewers for their contribution to the peer review of this work

in dogs)

D.ButlerJ.FilippatosG.FerreiraJ

This raises questions regarding the actual cytosolic NADP redox state and how variable it might be under different conditions or in different organisms

Overall quality of evidence The quality and consistency of each comparison was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines through GRADEpro (Balshem et al