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Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine

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doi: 10.3390/nu13093050 115 RadhakuttyAMangelsdorfBLDrakeSMRowlandASmithMDMangoniAAet al

TCA cycle intermediates were undetectable when [ 15 N, 13 C 5 ]valine was used as substrate, likely reflecting the low intrinsic levels of BCAT in the human liver and the further decrease in expression of metabolic genes (including BCAT) known to occur upon plating of hepatocytes

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Microbiota composition alone performed poorly (EV 2%) whilst diet, another purported major contributor to TMAO production, explained less than 5% of TMAO variance