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It also drives macrophage polarization toward an M1 phenotype, a state characterized by pro-inflammatory properties conducive for inducing tumoricidal activity

Astrocytes sense extracellular changes through receptors such as pattern recognition receptors and cytokine receptors, detecting pathogens, A aggregates or inflammatory mediators 4,41

Deficiencies of B vitamins, magnesium, and vitamin D are particularly critical

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