SARS-CoV-2 S-2P (comprising proline substitutions at residues K986 and V987) is used as the target antigen in three gene-based vaccine candidates (mRNA vaccines by Moderna/National Institute of Allergy and Infectious Diseases (NIAID) and BioNTech/Pfizer and a recombinant Ad26 vaccine by Janssen Pharmaceutical Companies) and a protein-based candidate (by Novavax) 4,86,87,88,89,90,91,92,93,94,95,96 (Table 1)
In a toxicological evaluation study of glycerol as a cigarette ingredient, it was found that addition of glycerol at rates of 10 g or 15 g per 100 g tobacco led to a significant 9% increase of acrolein in the smoke (67 and 69 g/cigarette, respectively), compared to the glycerol addition rate of 5 g per 100 g tobacco (60 g acrolein/cigarette) and the control cigarettes (56 g acrolein/cigarette) [12]
Emerging evidence has demonstrated that CD44 can serve as a stimulator or promoter for EMT process through regulating related pathways [6]
Norfluoxetine (desmethylfluoxetine) the principal metabolite, is formed by N-demethylation of fluoxetine, which may be under polygenic control
Komatsu M, Kanda T, Urai H, Kurokochi A, Kitahama R, Shigaki S, Ono T, Yukioka H, Hasegawa K, Tokuyama H, Kawabe H, Wakino S, Itoh H (2018) NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism
Effect of cogarette smoke and its condensates on alveolar epithelial cell injury in vitro