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This initial period allows the body to adapt to NNMT inhibition while minimizing potential side effects

The randomized, double-blind, placebo-controlled trials were conducted over a period of 48 weeks and involved numerous intramuscular doses provided over several weeks and long-term safety monitoring was performed until week 74

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doi:10.1080/10409230490440541

293 Additional studies on the pathological mechanism of depression have suggested that the HPA axis is hyperactive in MDD patients and that sensitivity to negative feedback is decreased