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However, despite their potential advantages, both retinospheres and retinal organoids suffer from the limitation that RGCs, more so than other retinal neurons, eventually die in culture [60], potentially due to the lack of retrograde transport of survival cues, such as brain-derived neurotrophic factor (BDNF), from central subcortical targets

Vadhan-Raj S, Broxmeyer HE, Jeha S, Estey E, Andreeff M , Thompson P, Trahan-Rieger P, Garrison L

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Your doctor may also order a urine test to check for a urinary tract infection, or a chest X-ray if they suspect pneumonia