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In the serum, Fe 2+ is oxidized by ceruloplasmin to Fe 3+ and then binds with transferrin (TF) to form a TFFe 3+ complex, which is endocytosed through the cell membrane transferrin receptor 1 (TFR1) ( 3+ is reduced to Fe 2+ , and the latter is transported out by the divalent metal ion transporter 1 (DMT1) or the zinc-iron-regulatory protein family 8/14 (ZIP8/14) ( 2+ is involved in the unstable iron pool (LIP)