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Remarkably, carnosine, a naturally occurring dipeptide composed of -alanine and L-histidine, was identified as a consistently downregulated metabolite in both models ( Mechanistically, our in vitro data revealed that carnosine not only suppressed LPS-induced cytokine production in BMDMs but also inhibited their polarization toward the M1-like pro-inflammatory phenotype, which is known to exacerbate lung tissue damage (Yan et al., 2024

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It is a naturally occurring compound found primarily in muscle cells

After peptide exposure in the models, 5-hydroxyindoleacetic acid (5-HIAA) levels were monitored

Injuries are often best managed via proper diagnosis, rehabilitation, training, sleep and nutrition, Reddy says

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