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In mice, researchers observed that MOTS-c in muscle and blood drops as the animals age, coinciding with the onset of age-related insulin resistance

Depending on the study goal, it may be applied as a comparator peptide or as part of a panel designed to track changes in molecular readouts linked to neurobiology and neuroendocrine regulation

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Identification of SOCS-3 as a potential mediator of central leptin resistance

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