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10.1016/j.fct.2020.111229 96 RoccoA.CompareD.AngrisaniD.Sanduzzi ZamparelliM.NardoneG

Complex mechanisms are proposed to explain the anti-estrogenic nature of AhR in breast and other cancers [132, 133] that are associated with the direct interaction with ER, resulting in the inhibition of DNA binding and disruption of coactivator/repressor recruitment [134, 135], that are associated with the anti-proliferative and pro-apoptotic effects of AhR agonist [136]

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For example, normalization of ALT and AST levels can alleviate symptoms of liver dysfunction such as fatigue, abdominal discomfort, and jaundice, thereby improving patients quality of life and daily activity ability