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Research employing PET tracers targeting the mitochondrial translocator protein (TSPO), such as [ 8 F]DPA-714, has demonstrated that some PCC patients continue to exhibit widespread elevated TSPO signals in the brain up to two years post-infection, with the intensity of this increase being most pronounced in individuals with persistent fatigue and cognitive symptoms (147) Animal studies have further substantiated that the sustained elevation of TSPO-PET signals (lasting at least 50 days) following SARS-CoV-2 infection arises from the co-activation of microglia, astrocytes, and endothelial cells, and that this neuroinflammatory state can endure long after viral clearance in the peripheral tissues (154)

We want to emphasize that the Overall Hospital Quality Star Rating is a summary of quality measurements that are already publicly reported as part of CMS hospital quality reporting & payment programs, as a simple, easily interpreted score to assist consumers and the public in assessing a hospital's overall quality

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DPI was found to increase mitochondrial superoxide production in MNA cells, leading to the induction of an apoptotic cascade (16)

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