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According to a 2021 literature review spanning over 40 years of research, hCG therapy is considered the top choice for patients suffering from secondary hypogonadism because it triggers the body to produce testosterone and sperm without side effects on fertility, such as those seen in testosterone replacement therapy

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Many clinics offer it, however, this can be a very intense and not-so-pleasant process for patients due to the severity of side effects such as dizziness, nausea, vomiting, fever, chills, headache, diarrhea, burning at the injection site of vein, breathlessness, and decrease in blood pressure