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Major histocompatibility complex susceptibility genes, including HLA-DR3, HLA-DR4, HLA-DQ2, and HLA-DQ8, are shared by both diseases

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NAD+ operates across several distinct and complementary cellular mechanisms, making it unique among research compounds in its breadth of biological relevance: Redox Metabolism: NAD+ acts as a hydride-accepting electron carrier in central metabolic pathways glycolysis, the Krebs cycle, beta-oxidation of fatty acids, and the mitochondrial electron transport chain