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Acknowledgements Y.C.s laboratory is supported through research grants from the European Research Council (ERC) advanced grant ANGIOFAT (Project no 250021), the Swedish Research Council, the Swedish Cancer Foundation, the Swedish Childrens Cancer Foundation, the Strategic Research Areas (SFO)Stem Cell and Regenerative Medicine Foundation, the Karolinska Institute Foundation, the Karolinska Institute distinguished professor award, the Torsten Soderbergs Foundation, the Maud and Birger Gustavsson Foundation, the NOVO Nordisk Foundation-Advance grant, and the Knut and Alice Wallenbergs Foundation