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Kok EY, et al

In the pioneering work by Oberley and Buettner published more than four decades ago, these authors suggested for the first time the importance of suppressed SOD2 (Mn-SOD) expression in cancer (Oberley and Buettner 1979)

Specifically, Aldh2 / /FancD2 / mice develop aplastic anemia [34], and the disease severity of Japanese Fanconi anemia patients correlates with the presence of a dominant-negative ALDH2*2 allele [35]