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This variability may stem from the complex feedback networks involving ROS-mediated redox and phosphorylation modifications (Su et al., 2019

Their benefits are wide-ranging

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[2] Hydroxocobalamin is administered via intramuscular or intravenous injection to treat and prevent vitamin B deficiency, particularly in conditions like pernicious anemia where oral B absorption is impaired

Notably, a randomized, controlled, open-label, 6-month trial at multiple community-based treatment centers in England and Scotland demonstrated the superiority of BUP-XR over standard-of-care treatment (i.e., transmucosal buprenorphine or oral methadone), with a greater abstinence from opioids, higher likelihood of early OUD remission, longer retention in treatment, and reduced or lack of opioid craving [22]