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In addition, the increased expression level of CDK2 , which forms a complex with Cyclin E and Cyclin A and is a key kinase regulating the G1/S transition and S-phase progression, further corroborates the phenomenon of cell cycle deregulation

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AtGPX1 and AtGPX7 were also shown to regulate ROS and SA pathways, which affect leaf development, light acclimation, basal defence and cell death programmes 28

158 In a mouse model of pancreatic islet cell carcinoma, chronic exposure to elevated levels of Cu by adding 20 M CuSO 4 to the drinking water also accelerated tumor growth

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