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1b), were significantly increased in the culture filtrates from Mtb H37Rv under hypoxia

The two enzymes, phenylalanine ammonia-lyase 1 (PAL1) and isochorismate synthase 1 (ICS1), are the key enzymes in the SA synthesis pathway

Kern TS, Antonetti DA, Smith LE

Mechanistic investigations reveal a constellation of molecular mechanisms: downregulation of deoxycytidine kinase cripples drug activation, while ribonucleotide reductase overexpression replenishes nucleotide pools