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Risk Factors include: Long-term poor blood sugar control (primary risk factor) Cardiovascular disease Age Male gender Elevated triglycerides High body mass index Smoking and excess alcohol consumption Diagnosis and Treatment Diagnosis Presence of characteristic symptoms including lower extremity numbness, pain, sensitivity, dryness, muscle weakness/wasting, difficulty walking, and loss of temperature sensation Physical exam Fasting blood glucose, hemoglobin A1C, CBC/Chemistry panel, others Nerve conduction studies or electromyograms on the foot Treatment Judicious tight blood sugar control is paramount in controlling progression of diabetic neuropathy

Accessed August 19, 2020

Size exclusion chromatography with in-line multi-angle light scattering (SEC-MALS) was used to characterize the samples

2-[[[(1,1-Dimethyl-2-hydroxyethyl)amino]carbonyl]amino]-N-(2,6-dimethylphenyl)-6-benzothiazolecarboxamide

Peptides are different from healthy proteins since they are much shorter and have a various framework

Vertuani et al., 2004)