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Briefly, plasma samples were deproteinized using 5% 5-sulfosalicylic acid, and 10 L of each sample was added to 150 L working mixture reagent in a 96 well-plate and incubated at room temperature for 5 minutes

10.1007/s11739-021-02685-0 44

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One drop of GenTeal eye gel (corneal lubricant) was applied to the cornea to prevent dehydration and to allow electrical contact with the recording electrode

Furthermore, clinical evidence implicates ApoE4s interaction with A is related to increased Tau deposition in AD vulnerable regions in the brain (Therriault et al., 2021), which mirrors the importance of A in the acceleration of AD Tau dynamics (Lee et al., 2022)

In the present study, elevated PGA levels were observed among 89% of symptomatic TTR-V30M patients and in 63% of asymptomatic carriers relative to the median of healthy controls (Table 1)