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GR can perform its enzymatic activity in the cytoplasm, but also in the ER and within lysosomes, mitochondria and the nucleus

Brenner, C., Galluzzi, L., Kepp, O

Furthermore, a phase I trial (NCT04868773) assessing the combination of cabozantinib with trifluridine/tipiracil (TAS-102) in mCRC patients is currently ongoing