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This is in stark contrast to traditional chemotherapy and many targeted therapies, which typically report severe adverse events in 30% to 60% of cases ( 3 Key bottlenecks and challenges in OV-based immunotherapy In clinical practice, patient responses to oncolytic virus (OV) therapy vary significantly ( Table 5 ):Patients with BRAF wild-type tumors exhibit significantly longer disease-free survival than those with BRAF mutations (P = 0.04), with the former achieving a local objective response rate (ORR) of 80%, compared to 65% in the latter ( Table 5 Efficacy of OV therapy across distinct melanoma subtypes

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doi: 10.1007/bf01300291 55 ReedDEBarajas-LopezCCottrellGVelazquez-RochaSDeryOGradyEFet al