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The OH depolymerizes GI mucin, inactivates pyruvate dehydrogenase, an essential mitochondrial enzyme, and damages mitochondrial RNA and DNA in the GI tract (113)

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PMID: 30282322

Nitroxides are radicals proposed as ATs

Interestingly, the most common hematological condition in CRC patients is iron deficiency, occurring in about 60% of diagnosed individuals [16, 52]

Meltzer PC, Butler D, Deschamps JR, Madras BK (2006) 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors