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10.1016/j.jaci.2020.06.024 31 CencioniM

GLP-1 RAs demonstrate metabolic efficacy but present diverse adverse events

Growing evidence implicates oxidative stress and mitochondrial dysfunction in fibromyalgia (FM), prompting interest in redox-modulating therapies ( High-dose thiamine (6001,800 mg/day) has shown promise in improving fatigue and pain in FM, likely by enhancing mitochondrial function and reducing oxidative stress ( NRF2-activating agents may improve both pain and sleep in FM by enhancing antioxidant defenses, mitochondrial function, and reducing neuroinflammation ( Melatonin supplementation (3 mg/day) has been shown to improve objective and subjective sleep quality, increase 6-sulfatoxymelatonin levels, and enhance total antioxidant capacity in FM patients, suggesting dual chronobiotic and antioxidant benefits ( Mitochondrial-targeted therapies such as CoQ10, alpha-lipoic acid (ALA), and carnitine have been investigated for their role in improving ATP production, reducing oxidative stress, and enhancing cellular metabolism

Exercise can also help manage weight and reduce the risk of chronic diseases

Preparation and characterization of L-[5-11C]-glutamine for metabolic imaging of tumors

Evens complexion: Supports more uniform skin tone over time