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The independent acquisition of the CSD in two clades, primates and muroids, at roughly the same epoch ~75 MYA is interesting, and could arise from an environmental change, for example in the oxygenation of the Earth's atmosphere

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895 In D-galactose-induced aging mice, the vitamin D receptor activator 1,25-(OH) 2 -D 3 alleviates D-galactose-induced osteoblast ferroptosis, manifested by improved mitochondrial morphology and decreased lipid peroxidation markers, and the mechanism may be related to the activation of the Nrf2/GPX4 signaling pathway to reduce osteoblast ferroptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.De Rosa S.C., Zaretsky M.D., Dubs J.G., Roederer M., Anderson M., Green A., Mitra D., Watanabe N., Nakamura H., Tjioe I., et al

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Modification of the site abolished enzymatic activity of thioredoxin