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Treatment involves dietary optimisation, oral supplementation for mild deficiency, or intramuscular hydroxocobalamin injections for significant deficiency or neurological involvement

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Consequently, the transformation of LC3-I to the autophagosome-associated form LC3-II is weakened, thereby reducing Beclin-1 and autophagy-related gene 5 expression and decreasing autophagy vesicle formation [129]

[....In an editorial in the same issue, Martha Morris, Sc.D., of Rush y in Chicago wrote that the Schaefer trial provides the first evidence that direct measurement of DHA in plasma is related to lower Alzheimer's risk