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As with lipedema, obesity is also a strong exacerbator of lymphedema (lymph fluid accumulation/swelling), can induce the onset of lymphedema in patients predisposed to it, and at high enough levels of obesity, can even induce lymphedema in patients who have no known predisposing risk factors

Cordes, H., Thiel, C., Baier, V., Blank, L

doi: 10.1080/09603123.2022.2093841

Mohan RA, Bosada FM, van Weerd JH, van Duijvenboden K, Wang J, Mommersteeg MTM, Hooijkaas IB, Wakker V, de Gier-de Vries C, Coronel R, Boink GJJ, Bakkers J, Barnett P, Boukens BJ, Christoffels VM

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Essential functions of the transcription factor Npas4 in neural circuit development, plasticity, and diseases