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Haahtela T, Holgate S, Pawankar R, Akdis CA, Benjaponpitak S, Caraballo L, Demain J, Portnoy J, von Hertzen L, WAO Special Committee on Climate Change and Biodiversity

It regulates neuronal firing patterns and frequencies, enhancing information encoding efficiency in the motor cortex while optimizing the excitation-inhibition balance, thereby improving the overall functional state of neural networks (Marino et al., 2023)

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Toxic levels of methotrexate can be rapidly and effectively decreased by intravenous administration of glucarpidase, which has been shown to induce a 99% or greater sustained reduction of serum methotrexate levels (Widemann 2014)