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For instance, polymeric nanomaterials like lipids, alginate, chitosan, gelatin, PEG, PCL, and PLGA are used to nano-encapsulate extracts from various plants such as Mentha piperita , Lycium barbarum , Centella asiatica , and Passiflora serratodigitata, etc

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These findings highlight the importance of brain endothelial CYP1B1 in maintaining BBB integrity, as its deficiency exacerbated Mn-induced BBB disruption, increased brain Mn accumulation, and worsened dopaminergic neurodegeneration, underscoring the critical role of the endothelium in mediating Mn neurotoxicity

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