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Nat Rev Drug Discov 4(5):387398

At the beginning of HCC growth in these mice, Wnt signaling, DNA hypomethylation, overexpression of DNA methyltransferases 1 and 3b, and activation of Gadd45a, Pak1, Mapk3 , and Dusp3 genes of the MAPK signaling were found [1]

Moreover, the research by single-cell RNA sequencing (SC-RNAseq) has revealed that the molecular changes underlying human skin aging are associated with cell-type-specific senescent genes