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Description

Humanin is an endogenous activator of chaperone-mediated autophagy

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Neutralizing antibody against PAI-1 attenuated p65 activation in IL-1 treated hepatocytes and blocked PAI-1 induction completely, suggesting the freely released PAI-1 is required to fully activate p65 and induce PAI-1

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Transmission electron microscopy revealed mitochondrial membrane rupture, fragmentation, and mitochondrial cristae fragmentation and disappearance

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The gut microbiota plays a crucial role in various aspects of human digestion, nutrient absorption, biological barrier function, immune regulation, and metabolism (13)

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The liver enzyme ASS1 has also been suggested as a specific indicator of liver injury in mouse models

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