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GPX-4s decreased activity, followed by increased activity of ACSL4, leads to iron accumulation and induction of ferroptosis (He and Shi 2023)

Miro1 possesses multiple lysine residues that undergo ubiquitination, and impairment of Miro1 ubiquitination hinders the translocation of E3 ubiquitin ligase Parkin (Lpez-Domnech et al., 2021), leading to delayed mitophagy in response to damaged mitochondria (Gupta et al., 2022

Conversely, astrocytes also have beneficial roles during PD progression [21-22]

Cell 144 PompellaA.VisvikisA.PaolicchiA.De TataV.CasiniA

Unfortunately, endometriosis is a chronic condition and there is no cure

Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3