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Functions of NQO1 in cellular protection and CoQ 10 metabolism and its potential role as a redox sensitive molecular switch

Neurobiol Dis 18(3):618627 Spindler M, Beal MF, Henchcliffe C (2009) Coenzyme Q10 effects in neurodegenerative disease

A phase II nonrandomized trial evaluating mirtazapine, a tetracyclic antidepressant, administered for 8 weeks to cancer patients without depression, reported that mirtazapine-treated patients gained weight and had an improved appetite.[43] In an exploratory study, olanzapine treatment of cancer patients with cachexia who were receiving active chemotherapy showed a nonsignificant trend toward improved weight.[44] Olanzapine has also been used in combination with megestrol acetate in advanced cancer, with results suggesting benefit.[45] It may be useful for patients on chemotherapy who have difficult-to-control nausea and weight loss

Clearance of blood urea in turn requires an osmotic gradient during its renal excretion, thus causing diuresis [114, 115]

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Subgroup analysis also suggested that chemotherapy could affect serum VitB3 and VitB5 concentrations in breast cancer patients, but there was no significant difference in serum VitB3 and VitB5 levels in breast cancer patients receiving different chemotherapy regimings