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Golding points out that unless the enterohepatic circulation is disrupted, holotranscobalamin levels wont significantly decrease until the livers B12 stores are depleted (Golding, 2016)

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10.1089/neu.1998.15.217 J

This protective action is mediated by a network of interconnected mechanisms: it suppresses neuronal apoptosis by modulating key regulators like the Bax/Bcl-2 balance and reducing caspase-3 activity

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As recurrent chronic pancreatitis can lead to exocrine pancreatic insufficiency, feline trypsin-like immunoreactivity should also be assessed especially if hypocobalaminaemia is also present (intrinsic factor for cobalamin absorption is exclusively produced in the pancreas in cats) 4