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Analysis of interleukin-1 (IL-1) and interleukin-8 (IL-8) expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and/or sensitization

It also acts on the enzyme tyrosinase, which plays a role in melanin production, reducing the formation of dark pigments in the skin

He also says this ingredient is safe to use long-term since it's a non-hydroquinone brightening agent

PMID: 22005198

Importantly, no adverse events were recorded, and all patients reported positive experiences with use of the serum