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This study found that in animals treated with 2-Aminobicyclo [2, 2, 1] heptane-2-carboxylic acid (BCH), a nonmetabolic analogue of leucine, the renal arteriovenous ammonia level change was greater than in the liver, indicating that hyperammonemia in GDH-HI patients is mainly induced due to increased renal ammonia production, instead of abnormalities in urea synthesis in the liver

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Biol Psychiatry 78:702710 Mandal PK, Goel A, Bush AI, Punjabi K, Joon S, Mishra R, Tripathi M, Garg A, Kumar NK, Sharma P, Shukla D, Ayton SJ, Fazlollahi A, Maroon JC, Dwivedi D, Samkaria A, Sandal K, Megha K, Shandilya S (2022) Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimers disease compared with healthy elderly participants

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