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Other mechanisms underlying excessive ER-phagy Loperamide and pimozide induce excessive ER-phagy in patients with GBM and upregulation of cholesterol and lipid anabolism, leading to the accumulation of cholesterol and lipids (predominantly ceramide) in lysosomes [47]

Moreover, in xenograft models (human OSCC tumors implanted in mice), curcumin treatment has been shown to inhibit tumor growth and reduce lung metastases (Davoodvandi et al., 2021)

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