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Lastly, elevated malondialdehyde (MDA) and decreased glutathione (GSH) levels indicate that chronic exposure to large dosages of TMAO can induce oxidative stress and inflammation in the liver [38]

In addition, the level of MDA, the end-product of lipid peroxidation, was found to be significantly reduced in GCs after LC pre-treatment, suggesting that LC may alleviate the cell damage caused by OS and the mitochondrial oxidative respiratory chain

The axis often modulates intricate biological mechanisms via bidirectional communication between the enteric nervous system (ENS) and the CNS, which is facilitated by proinflammatory cytokines, neuropeptides and neurotransmitters, vagal afferents, stress hormones, immune-mediators, SCFAs and other microbiome metabolites

This can feel like you're having "skipped beats," but you're actually not

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