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In the absence of synthesis of GSH in the transulfuration pathway, the effects of heme-oxygenase in the first step toward heme synthesis would be expected to lead to increased downstream porphyrin synthesis and heme formation

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Merlo S, Spampinato SF, Beneventano M, Sortino MA (2018) The contribution of microglia to early synaptic compensatory responses that precede beta-amyloid-induced neuronal death

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