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Here we present the cryo-EM structure of system xc in both the apo and glutamate bound states

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11,51,52 The receptor-arrestin complex also serves as a scaffold for over 20 different kinases, including mitogen-activated protein (MAP) kinases, ERK1/2, p38 kinases, and c-Jun N-terminal kinases, activating G-protein independent signaling pathway

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