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In the SN of PD patients, activated microglia and reactive astrocytes have been found to release pro-inflammatory factors that induce neuronal death (Imamura et al., 2003

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doi: 10.1016/j.immuni.2019.11.009 7 MillsELKellyBLoganACostaASHVarmaMBryantCEet al

Klisyri can now be used to treat lesions up to 100 cm 2 caused by the pre-cancerous dermatological condition, after safety and tolerability profiles were consistent with original pivotal trial results

Mechanistically, folic acid attenuates activation of the NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome, thereby suppressing glial activation and neuroinflammation as well as preserving mitochondrial integrity through p53-peroxisome proliferator-activated receptor coactivator 1 (PGC-1) pathway [174]