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Because Met and CQ target these pathways, they are excellent options for addressing the resistance mechanisms of B-ALL

Caceres LG, Uran SL, Zorrilla Zubilete MA, Romero JI, Capani F, et al

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Once recruited, FSP1 suppresses lipid hydroperoxides by catalyzing the reduction of ubiquinone (CoQ 10 ) to its hydroquinone form, ubiquinol (CoQ 10 -H 2 ), and the consumption of NAD(P)H [3]

It has been shown that in DU145 cells, diosmin led to radical oxidative stress by increasing the overall production of reactive oxygen species (ROS), which caused changes in the potential of the mitochondrial membrane and, as a consequence, apoptosis and cell death [ 11 ]